Wobble hypothesis

Wobble hypothesis

1. Wobble hypothesis explains the phenomena of multiple codons coding for the code for a single amino acid. 
2. According to this theory the base in the first position of the anticodon on tRNA is an abnormal base which is able to pair with single type of nitrogenous bases in the third position of codon on m-RNA.
3. Our main wobble base pairs are guanine-uracil (G-U), hypoxanthine-uracil (I-U), hypoxanthine-adenine (I-A), and hypoxanthine-cytosine (I-C).
4. It does not follow the Watson and crick base pair rule.